Ether-phosphatidylcholine characterized by consolidated plasma and liver lipidomics is a predictive biomarker for valproic acid-induced hepatic steatosis
Author:
Affiliation:
1. Toxicology Research Lab., Central Pharmaceutical Research Institute, JAPAN TOBACCO Inc.
2. Division of Medicinal Safety Science, National Institute of Health Sciences
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/43/6/43_395/_pdf
Reference41 articles.
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2. Aires, C.C., Ijlst, L., Stet, F., Prip-Buus, C., de Almeida, I.T., Duran, M., Wanders, R.J. and Silva, M.F. (2010): Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis. Biochem. Pharmacol., 79, 792-799.
3. Blumberg, P.M., Acs, G., Acs, P., Areces, L.B., Kazanietz, M.G., Lewin, N.E. and Szallasi, Z. (1995): Protein kinase C in cell signaling: strategies for the development of selective inhibitors. Agents Actions Suppl., 47, 87-100.
4. Chapman, A., Keane, P.E., Meldrum, B.S., Simiand, J. and Vernieres, J.C. (1982): Mechanism of anticonvulsant action of valproate. Prog. Neurobiol., 19, 315-359.
5. Chavez-Blanco, A., Segura-Pacheco, B., Perez-Cardenas, E., Taja-Chayeb, L., Cetina, L., Candelaria, M., Cantu, D., Gonzalez-Fierro, A., Garcia-Lopez, P., Zambrano, P., Perez-Plasencia, C., Cabrera, G., Trejo-Becerril, C., Angeles, E. and Duenas-Gonzalez, A. (2005): Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study. Mol. Cancer, 4, 22.
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