Benzo[a]pyrene induces pyroptotic and autophagic death through inhibiting PI3K/Akt signaling pathway in HL-7702 human normal liver cells
Author:
Affiliation:
1. College of Food Engineering and Nutritional Science, Shaanxi Normal University, China
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/44/2/44_121/_pdf
Reference29 articles.
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2. Alharthy, K.M., Albaqami, F.F., Thornton, C., Corrales, J. and Willett, K.L. (2017): Mechanistic Evaluation of Benzo[a]pyrene’s Developmental Toxicities Mediated by Reduced Cyp19a1b Activity. Toxicol. Sci., 155, 135-147.
3. Clements, W.H., Oris, J.T. and Wissing, T.E. (1994): Accumulation and food chain transfer of fluoranthene and benzo[a]pyrene in Chironomus riparius and Lepomis macrochirus. Arch. Environ. Contam. Toxicol., 26, 261-266.
4. Duan, J., Yu, Y., Li, Y., Wang, Y. and Sun, Z. (2016): Inflammatory response and blood hypercoagulable state induced by low level co-exposure with silica nanoparticles and benzo[a]pyrene in zebrafish (Danio rerio) embryos. Chemosphere, 151, 152-162.
5. Hu, C., Yang, J., He, Q., Luo, Y., Chen, Z., Yang, L., Yi, H., Li, H., Xia, H., Ran, D., Yang, Y., Zhang, J., Li, Y. and Wang, H. (2018): CysLTR1 blockage ameliorates liver injury caused by aluminum-overload via PI3K/AKT/mTOR-mediated autophagy activation in vivo and in vitro. Mol. Pharm., 15, 1996-2006.
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