A 13-week feeding toxicity study of L-threonine in rats with a recovery period of 5 weeks
Author:
Affiliation:
1. Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD.
2. Gotemba Laboratory, BoZo Research Center Inc.
3. Public Relations Department, KYOWA HAKKO BIO CO., LTD.
Publisher
Japanese Society of Toxicology
Link
https://www.jstage.jst.go.jp/article/fts/1/2/1_49/_pdf
Reference9 articles.
1. Blin, O., Pouget, J., Aubrespy, G., Guelton, C., Crevat, A. and Serratrice, G. (1992): A double-blind placebo-controlled trial of L-threonine in amyotrophic lateral sclerosis. J. Neurol., 239, 79-81.
2. Defa, L., Changting, X., Shiyan, Q., Jinhui, Z., Johnson, E.W. and Thacker, P.A. (1999): Effects of dietary threonine on performance, plasma parameters and immune function of growing pigs. Anim. Feed Sci. Technol., 78, 179-188.
3. Fujisawa, K., Yagasaki, K., Miura, Y. and Funabiki, R. (1995): Improvement of hyperlipidemia and proteinuria without noticeable growth retardation by feeding a methionine and threonine supplemented low-casein diet to nephritic rats. Biosci. Biotechnol. Biochem., 59, 1896-1900.
4. Growdon, J.H., Nader, T.M., Schoenfeld, J. and Wurtman, R.J. (1991): L-threonine in the treatment of spasticity. Clin. Neuropharmacol., 14, 403-412.
5. Gullino, P., Winitz, M., Birnbaum, S.M., Cornfield, J., Otey, M.C. and Greenstein, J.P. (1956): Studies on the metabolism of amino acids and related compounds in vivo. I. Toxicity of essential amino acids, individually and in mixtures, and the protective effect of L-arginine. Arch. Biochem. Biophys., 64, 319-332.
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