The <i>in vivo</i> Pig-a gene mutation assay is applied to study the genotoxicity of procarbazine hydrochloride in Sprague-Dawley rats-Reference-Cited by-同舟云学术

The in vivo Pig-a gene mutation assay is applied to study the genotoxicity of procarbazine hydrochloride in Sprague-Dawley rats

Published:2016 Issue:4 Volume:3 Page:167-175
ISSN:2189-115X
Container-title:Fundamental Toxicological Sciences
language:en
Short-container-title:Fundam. Toxicol. Sci.

Author:

Pu Jiang¹²,Deng Yuanyuan¹³,Tan Xiaoyan¹²,Chen Gaofeng¹²,Zhu Cong¹²,Qi Naisong¹,Wen Hairuo¹,Guo Jun¹,Wang Xin¹,Qiu Yuwen²,Liang Jinqiang²,Fu Xinlu²,Hu Yanping¹,Song Jie¹,Geng Xingchao¹,Wang Chao¹,Zhang Lin¹,Huang Zhiying²,Li Bo¹,Wang Xue¹

Affiliation:

1. National Centre for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, China

2. Sun Yat-sen University, China

3. National Centre for Safety Evaluation of Drugs, China

Publisher

Japanese Society of Toxicology

Link

https://www.jstage.jst.go.jp/article/fts/3/4/3_167/_pdf

Reference20 articles.

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2. Bessler, M., Mason, P.J., Hillmen, P., Miyata, T., Yamada, N., Takeda, J. et al. (1994): Paroxysmal nocturnal haemoglobinuria (pnh) is caused by somatic mutations in the pig-a gene. EMBO J., 13, 110-117.

3. Bhalli, J.A., Pearce, M.G., Dobrovolsky, V.N. and Heflich, R.H. (2011): Manifestation and persistence of pig-a mutant red blood cells in c57bl/6 mice following single and split doses of n -ethyl- n -nitrosourea. Environ. Mol. Mutagen., 52, 766-773.

4. Dobrovolsky, V.N., Heflich, R.H. and Ferguson, S.A. (2012): The frequency of pig-a mutant red blood cells in rats exposed in utero to n -ethyl- n -nitrosourea. Environ. Mol. Mutagen., 53, 440-450.

5. Dertinger, S.D., Bryce, S.M., Souk, P. and Avlasevich, S.L. (2011): When pigs fly: immunomagnetic separation facilitates rapid determination of pig-a mutant frequency by flow cytometric analysis. Mutat. Res., 721, 163-170.

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1. Assessment of the Pig-a , micronucleus, and comet assay endpoints in rats treated by acute or repeated dosing protocols with procarbazine hydrochloride and ethyl carbamate;Environmental and Molecular Mutagenesis;2018-09-21

2. Multi-laboratory evaluation of 1,3-propane sultone, N -propyl- N -nitrosourea, and mitomycin C in the Pig-a mutation assay in vivo;Mutation Research/Genetic Toxicology and Environmental Mutagenesis;2018-07