Investigation of solvents that can be used as vehicles to evaluate poorly soluble compounds in short-term oral toxicity studies in rats
Author:
Affiliation:
1. Preclinical Research Unit, Sumitomo Pharma Co., Ltd.
Publisher
Japanese Society of Toxicology
Link
https://www.jstage.jst.go.jp/article/fts/11/2/11_69/_pdf
Reference18 articles.
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4. Gad, S.C., Spainhour, C.B., Shoemake, C., Pallman, D.R., Stricker-Krongrad, A., Downing, P.A., Seals, R.E., Eagle, L.A., Polhamus, K. and Daly, J. (2016): Tolerable levels of nonclinical vehicles and formulations used in studies by multiple routes in multiple species with notes on methods to improve utility. Int. J. Toxicol., 35, 95-178.
5. Gopinathan, S., O’Neill, E., Rodriguez, L.A., Champ, R., Phillips, M., Nouraldeen, A., Wendt, M., Wilson, A.G. and Kramer, J.A. (2013): In vivo toxicology of excipients commonly employed in drug discovery in rats. J. Pharmacol. Toxicol. Methods, 68, 284-295.
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