CARCINOscreen®: New short-term prediction method for hepatocarcinogenicity of chemicals based on hepatic transcript profiling in rats
Author:
Affiliation:
1. Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute, Japan (CERI)
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/39/5/39_725/_pdf
Reference13 articles.
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2. Ellinger-Ziegelbauer, H., Gmuender, H., Bandenburg, A. and Ahr, H.J. (2008): Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies. Mutat. Res., 637, 23-39.
3. Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Ogiso, T., Masui, T., Imaida, K., Fukushima, S. and Asamoto, M. (1988): Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats--an approach for a new medium-term bioassay system. Carcinogenesis, 9, 387-394.
4. Ito, N, Tamano, S. and Shirai, T. (2003): A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci., 94, 3-8.
5. Mathijs, K., Brauers, K.J., Jennen, D.G., Boorsma, A., vanHerwijnen, M.H., Gottschalk, R.W., Kleinjans, J.C. and van Delft, J.H. (2009): Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time. Toxicol. Sci., 112, 374-384.
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