Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice

Author:

Lee Jin-Yong12,Hwang Gi-Wook1,Kim Min-Seok1,Takahashi Tsutomu1,Naganuma Akira1

Affiliation:

1. Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University

2. Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference15 articles.

1. Adler, M.W. and Rogers, T.J. (2005): Are chemokines the third major system in the brain? J. Leukoc. Biol., 78, 1204-1209.             

2. Gamo, K., Kiryu-Seo, S., Konishi, H., Aoki, S., Matsushima, K., Wada, K. and Kiyama, H. (2008): G-protein-coupled receptor screen reveals a role for chemokine receptor CCR5 in suppressing microglial neurotoxicity. J. Neurosci., 28, 11980-11988.          

3. Gorter, J.A., van Vliet, E.A., Aronica, E., Breit, T., Rauwerda, H., Lopes da Silva, F.H. and Wadman, W.J. (2006): Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J. Neurosci., 26, 11083-11110.                 

4. Hwang, G.W., Lee, J.Y., Ryoke, K., Matsuyama, F., Kim, J.M., Takahashi, T. and Naganuma, A. (2011): Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury. J. Toxicol. Sci., 36, 389-391.

5. Hwang, G.W., Ryoke, K., Takahashi, T. and Naganuma, A. (2010a): Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells. J. Toxicol. Sci., 35, 941-944.        

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