Assessment of human epidermal model LabCyte EPI-MODEL for in vitro skin irritation testing according to European Centre for the Validation of Alternative Methods (ECVAM)-validated protocol

Author:

Katoh Masakazu1,Hamajima Fumiyasu1,Ogasawara Takahiro1,Hata Ken-ichiro1

Affiliation:

1. R&D Department, Japan Tissue Engineering Co., Ltd.

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference13 articles.

1. Botham, P.A., Earl, L.K., Fentem, J.H., Roguet, R. and van de Sandt, J.J.M. (1998): Alternative methods for skin irritation testing: the current status: ECVAM skin irritation task force report 1. Altern. Lab. Anim., 26, 195-211.

2. Cotovio, J., Grandidier, M.H., Portes, P., Roguet, R. and Rubinstenn, G. (2005): The in vitro acute skin irritation of chemicals: Optimization of the EpiSkin prediction model within the framework of the ECVAM validation process. Altern. Lab. Anim., 33, 329-349.

3. ECVAM SIVS. (2007): Performance standards for applying human skin models to in vitro skin irritation testing. Website: http://ecvam.jrc.it/indexs.html.

4. El, G., Siamari, R., Willemze, R. and Ponec, M. (2008): Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines. Toxicol in Vitro, 22, 1311-1320.

5. A prevalidation study on in vitro tests for acute skin irritation

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