Effects of microsampling on toxicity assessment of hematotoxic compounds in a general toxicity study in rats-Reference-Cited by-同舟云学术

Effects of microsampling on toxicity assessment of hematotoxic compounds in a general toxicity study in rats

Published:2022 Issue:7 Volume:47 Page:269-276
ISSN:0388-1350
Container-title:The Journal of Toxicological Sciences
language:en
Short-container-title:J. Toxicol. Sci.

Author:

Tochitani Tomoaki¹,Sasaki Yasuhiro¹,Nishimura Naoe¹,Fujii Yuta¹,Iwaisako Takayuki¹,Umeya Naohisa¹,Hashimoto Masayo¹,Inada Hiroshi¹,Chihara Kazuhiro¹,Miyawaki Izuru¹

Affiliation:

1. Preclinical Research Unit, Sumitomo Pharma Co., Ltd.

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Link

https://www.jstage.jst.go.jp/article/jts/47/7/47_269/_pdf

Reference8 articles.

1. Caron, A., Lelong, C., Bartels, T., Dorchies, O., Gury, T., Chalier, C. and Benning, V. (2015): Clinical and anatomic pathology effects of serial blood sampling in rat toxicology studies, using conventional or microsampling methods. Regul. Toxicol. Pharmacol., 72, 429-439.

2. Hattori, N., Takumi, A., Saito, K. and Saito, Y. (2020): Effects of serial cervical or tail blood sampling on toxicity and toxicokinetic evaluation in rats. J. Toxicol. Sci., 45, 599-609.

3. Hejtmancik, M.R., Ryan, M.J., Toft, J.D., Persing, R.L., Kurtz, P.J. and Chhabra, R.S. (2002): Hematological effects in F344 rats and B6C3F1 mice during the 13-week gavage toxicity study of methylene blue trihydrate. Toxicol. Sci., 65, 126-134.

4. ICH. (2017): ICH S3A Q&A focus on microsampling. (https://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S3A/S3AIWG_Step4_2017_1116.pdf).

5. Molyneux, G., Gibson, F.M., Chen, C.M., Marway, H.K., McKeag, S., Mifsud, C.V., Pilling, A.M., Whayman, M.J. and Turton, J.A. (2008): The haemotoxicity of azathioprine in repeat dose studies in the female CD-1 mouse. Int. J. Exp. Pathol., 89, 138-158.

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