Reactive oxygen species (ROS) assay-based photosafety screening for complex ingredients: Modification of the ROS assay protocol

Author:

Ohtake Hiroto1,Tokuyoshi Yasuharu1,Iyama Yosuke1,Nukaga Takumi2,Nishida Hayato2,Ohtake Toshiyuki2,Hirota Morihiko2,Yamada Kohei1,Seto Yoshiki1,Sato Hideyuki1,Kouzuki Hirokazu2,Onoue Satomi1

Affiliation:

1. Laboratory of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka

2. Shiseido Global Innovation Center

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference22 articles.

1. EFSA. (2012): Compendium of botanicals reported to contain naturally occuring substances of possible concern for human health when used in food and food supplements. EFSA J., 10, 2663.

2. EMA. (2021): Assessment report on Hypericum perforatum L., herba 2nd Draft – Revision 1. ((HMPC), C.o.H.M.P., ed.).

3. ICH. (2014): ICH guideline S10, Guidance on photosafety evaluation of pharmaceuticals, International Council on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use.

4. IFRA (2021): IFRA Standards-50th Amendment.

5. Iyama, Y., Sato, H., Seto, Y. and Onoue, S. (2019): A new photosafety screening strategy based on in chemico photoreactivity and in vitro skin exposure for dermally-applied chemicals. Toxicol. Lett., 317, 45-52.

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