A novel glucokinase activator TMG-123 causes long-lasting hypoglycemia and impairs spermatogenesis irreversibly in rats
Author:
Affiliation:
1. Graduate School of Veterinary Science, Azabu University
2. TEIJIN PHARMA LIMITED, Teijin Institute for Bio-medical Research
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/46/3/46_115/_pdf
Reference24 articles.
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2. Bieber, A.M., Marcon, L., Hales, B.F. and Robaire, B. (2006): Effects of chemotherapeutic agents for testicular cancer on the male rat reproductive system, spermatozoa, and fertility. J. Androl., 27, 189-200.
3. Bonds, D.E., Miller, M.E., Bergenstal, R.M., Buse, J.B., Byington, R.P., Cutler, J.A., Dudl, R.J., Ismail-Beigi, F., Kimel, A.R., Hoogwerf, B., Horowitz, K.R., Savage, P.J., Seaquist, E.R., Simmons, D.L., Sivitz, W.I., Speril-Hillen, J.M. and Sweeney, M.E. (2010): The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ, 340, b4909.
4. Boussouar, F. and Benahmed, M. (2004): Lactate and energy metabolism in male germ cells. Trends Endocrinol. Metab., 15, 345-350.
5. Creasy, D.M. (2001): Pathogenesis of male reproductive toxicity. Toxicol. Pathol., 29, 64-76.
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