Farnesoid X receptor and liver X receptors regulate Oct3/4 expression by multiple feedback regulating system in normal renal-derived cells and renal adenocarcinoma cells

Author:

Fujino Tomofumi1,Sugizaki Kouta1,Kato Rei1,Beppu Masaki1,Murakami Satoshi1,Lee Hyunjung1,Oshima Toshiyuki1,Hayakawa Makio1

Affiliation:

1. Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference34 articles.

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2. Chiang, J.Y., Kimmel, R. and Stroup, D. (2001): Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). Gene, 262, 257-265.

3. Collins, J.L., Fivush, A.M., Watson, M.A., Galardi, C.M., Lewis, M.C., Moore, L.B., Parks, D.J., Wilson, J.G., Tippin, T.K., Binz, J.G., Plunket, K.D., Morgan, D.G., Beaudet, E.J., Whitney, K.D., Kliewer, S.A. and Willson, T.M. (2002): Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J. Med. Chem., 45, 1963-1966.

4. Flaveny, C.A., Griffett, K., El-Gendy, Bel-D., Kazantzis, M., Sengupta, M., Amelio, A.L., Chatterjee, A., Walker, J., Solt, L.A., Kamenecka, T.M. and Burris, T.P. (2015): Broad anti-tumor activity of a small molecule that selectively targets the warburg effect and lipogenesis. Cancer Cell, 28, 42-56.

5. Fujino, T., Maruko-Ohtake, A., Ohtake, Y., Kobayashi, T., Ando, K., Takeuchi, A., Ohkubo, Y. and Hayakawa, M. (2015): Farnesoid X receptor knockdown provides significant growth inhibition in hepatocellular carcinoma cells while it does not interfere with the proliferation of primary human hepatocyte-derived cells. J. Toxicol. Sci., 40, 501-508.

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