Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction-Reference-Cited by-同舟云学术

Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction

Published:2000-09 Issue:3 Volume:1 Page:257-262
ISSN:1470-3203
Container-title:Journal of the Renin-Angiotensin-Aldosterone System
language:en
Short-container-title:J Renin Angiotensin Aldosterone Syst

Author:

Yi Zhun Zhu ¹,Zhu Yi-Chun²,Jun Li ³,Schäfer Heiner⁴,Schmidt Wolfgang⁴,Tai Yao ⁵,Unger Thomas⁶

Affiliation:

1. Department of Pharmacology, University of Kiel, Germany, Department of Pharmacology, National University of Singapore, Singapore

2. Department of Pharmacology, University of Kiel, Germany, Department of Physiology, Shanghai Medical University, China

3. Department of Pharmacology, University of Kiel, Germany

4. Department of Internal Medicine, University Hospital of Kiel, Germany

5. Department of Physiology, Shanghai Medical University, China

6. Department of Pharmacology, University of Kiel, Germany, th.unger@ pharmakologie

Abstract

We investigated the haemodynamic parameters and the regulation of cardiac mRNA levels of the angiotensin receptor subtypes, AT1 and AT2, by the AT1-receptor antagonist losartan in rat heart during the acute phase of myocardial infarction. AT1- and AT2-receptor mRNA levels markedly increased at 30 minutes and peaked at 24 hours post myocardial infarction (12.6-fold increase for AT1- and 17.2-fold increase for AT2 compared with controls). Losartan significantly reduced mean blood pressure in sham-operated rats and decreased mean blood pressure and left ventricular end-diastolic pressure in myocardial infarction rats. However, the AT1- and AT2-receptor mRNA levels of losartan-treated rats showed a pattern similar to that of water-treated rats. The time-dependent increase of AT 1- and AT2receptor mRNA levels is associated with the early remodelling process of non-infarcted myocardium post MI and is independent of AT1-receptor blockade.

Publisher

Hindawi Limited

Subject

Endocrinology,Internal Medicine

Link

http://journals.sagepub.com/doi/pdf/10.3317/jraas.2000.039

Reference22 articles.

1. Substrate Metabolism, Hormone Interaction, and Angiotensin-Converting Enzyme Inhibitors in Left Ventricular Hypertrophy

2. Effects of the Early Administration of Enalapril on Mortality in Patients with Acute Myocardial Infarction

3. Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

Cited by 57 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Angiotensin AT2 receptors reduce inflammation and fibrosis in cardiovascular remodeling;Biochemical Pharmacology;2024-04

2. Crosstalk Between Abnormal Electrical Activity and Angiotensin II Cell Signaling in the Hyperglycemic Mammalian Heart;The Renin Angiotensin System in Cardiovascular Disease;2023

3. The Angiotensin AT₂Receptor: From a Binding Site to a Novel Therapeutic Target;Pharmacological Reviews;2022-09-30

4. Morpho-functional remodelling of the adult zebrafish (Danio rerio) heart in response to waterborne angiotensin II exposure;General and Comparative Endocrinology;2021-01

5. The Two-Way Switch Role of ACE2 in the Treatment of Novel Coronavirus Pneumonia and Underlying Comorbidities;Molecules;2020-12-31