Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites-Reference-Cited by-同舟云学术

Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites

Published:2010 Issue:3 Volume:25 Page:223-235
ISSN:1347-4367
Container-title:Drug Metabolism and Pharmacokinetics
language:en
Short-container-title:Drug Metabolism and Pharmacokinetics

Author:

Kamimura Hidetaka,Nakada Naoyuki,Suzuki Katsuhiro,Mera Ayako,Souda Kinya,Murakami Yuichi,Tanaka Kohichiro,Iwatsubo Takafumi,Kawamura Akio,Usui Takashi

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference60 articles.

1. The use of in vitro metabolism techniques in the planning and interpretation of drug safety studies;Wrighton;Toxicol. Pathol.,1995

2. Drug metabolites in safety testing;Baillie;Toxicol. Appl. Pharmacol.,2002

3. Metabolites and safety: What are the concerns, and how should we address them?;Smith;Chem. Res. Toxicol.,2006

4. Food and Drug Administration,2008

5. Food and Drug Administration,2010

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