Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na<sub>V</sub>1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver-Reference-Cited by-同舟云学术

Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na_V1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver

Published:2022-10-23 Issue:1 Volume:51 Page:67-80
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Asano Daigo,Nakamura Koichi,Nishiya Yumi,Shiozawa Hideyuki,Takakusa Hideo,Shibayama Takahiro,Inoue Shin-ichi,Shinozuka Tsuyoshi,Hamada Takakazu,Yahara Chizuko,Watanabe Nobuaki,Yoshinari Kouichi

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference42 articles.

1. CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate

2. Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase;Asano;Xenobiotica,2021

3. Prediction of metabolite-to-parent drug exposure: Derivation and application of a mechanistic static model;Callegari;Clin Transl Sci,2020

4. Comparison of p450 enzymes between cynomolgus monkeys and humans: p450 identities, protein contents, kinetic parameters, and potential for inhibitory profiles;Emoto;Curr Drug Metab,2013

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1. Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers;Xenobiotica;2023-09-02

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