Different Enzyme Kinetics of Midazolam in Recombinant CYP3A4 Microsomes from Human and Insect Sources

Author:

Christensen Hege,Mathiesen Liv,Postvoll Lillian W.,Winther Bjørn,Molden Espen

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference28 articles.

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2. Inhibition and induction of cytochrome P450 and the clinical implications;Lin;Clin. Pharmacokinet.,1998

3. Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors;Proctor;Xenobiotica,2004

4. Atypical kinetic profiles in drug metabolism reactions;Hutzler;Drug Metab. Dispos.,2002

5. Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches;Venkatakrishnan;Drug Metab. Dispos.,2000

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