A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates-Reference-Cited by-同舟云学术

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

Published:2009 Issue:1 Volume:24 Page:53-75
ISSN:1347-4367
Container-title:Drug Metabolism and Pharmacokinetics
language:en
Short-container-title:Drug Metabolism and Pharmacokinetics

Author:

Jamei Masoud,Dickinson Gemma L.,Rostami-Hodjegan Amin

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference150 articles.

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5. Modelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro-in vivo extrapolations (IVIVE);Gibson;Xenobiotica.,2007

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