NCCN Guidelines® Insights: B-Cell Lymphomas, Version 6.2023

Author:

Zelenetz Andrew D.1,Gordon Leo I.2,Abramson Jeremy S.3,Advani Ranjana H.4,Andreadis Babis5,Bartlett Nancy L.6,Budde L. Elizabeth7,Caimi Paolo F.8,Chang Julie E.9,Christian Beth10,DeVos Sven11,Dholaria Bhagirathbhai12,Fayad Luis E.13,Habermann Thomas M.14,Hamid Muhammad Saad15,Hernandez-Ilizaliturri Francisco16,Hu Boyu17,Kaminski Mark S.18,Karimi Yasmin18,Kelsey Christopher R.19,King Rebecca14,Krivacic Susan20,LaCasce Ann S.21,Lim Megan1,Messmer Marcus22,Narkhede Mayur23,Rabinovitch Rachel24,Ramakrishnan Praveen25,Reid Erin26,Roberts Kenneth B.27,Saeed Hayder28,Smith Stephen D.29,Svoboda Jakub30,Swinnen Lode J.31,Tuscano Joseph32,Vose Julie M.33,Dwyer Mary A.34,Sundar Hema34

Affiliation:

1. Memorial Sloan Kettering Cancer Center

2. Robert H. Lurie Comprehensive Cancer Center of Northwestern University

3. Massachusetts General Hospital Cancer Center

4. Stanford Cancer Institute

5. UCSF Helen Diller Family Comprehensive Cancer Center

6. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

7. City of Hope National Medical Center

8. Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

9. University of Wisconsin Carbone Cancer Center

10. The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

11. UCLA Jonsson Comprehensive Cancer Center

12. Vanderbilt-Ingram Cancer Center

13. The University of Texas MD Anderson Cancer Center

14. Mayo Clinic Comprehensive Cancer Center

15. St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center

16. Roswell Park Comprehensive Cancer Center

17. Huntsman Cancer Institute at the University of Utah

18. University of Michigan Rogel Cancer Center

19. Duke Cancer Institute

20. Consultant

21. Dana-Farber/Brigham and Women’s Cancer Center

22. Fox Chase Cancer Center

23. O’Neal Comprehensive Cancer Center at UAB

24. University of Colorado Cancer Center

25. UT Southwestern Simmons Comprehensive Cancer Center

26. UC San Diego Moores Cancer Center

27. Yale Cancer Center/Smilow Cancer Hospital

28. Moffitt Cancer Center

29. Fred Hutchinson Cancer Center

30. Abramson Cancer Center at the University of Pennsylvania

31. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

32. UC Davis Comprehensive Cancer Center

33. Fred & Pamela Buffett Cancer Center

34. National Comprehensive Cancer Network

Abstract

Novel targeted therapies (small molecule inhibitors, antibody–drug conjugates, and CD19-directed therapies) have changed the treatment landscape of relapsed/refractory B-cell lymphomas. Bruton’s tyrosine kinase (BTK) inhibitors continue to evolve in the management of mantle cell lymphoma (MCL), in both the relapsed/refractory and the frontline setting. Anti-CD19 CAR T-cell therapies are now effective and approved treatment options for relapsed/refractory follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and MCL. Bispecific T-cell engagers represent a novel immunotherapeutic approach for relapsed FL and DLBCL after multiple lines of therapies, including prior CAR T-cell therapy. These NCCN Guideline Insights highlight the significant updates to the NCCN Guidelines for B-Cell Lymphomas for the treatment of FL, DLBCL, and MCL.

Publisher

Harborside Press, LLC

Subject

Oncology

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