Gastrointestinal Alpha Heavy Chain Disease With Persistent Campylobacter Jejuni Colonization and Refractory Giardiasis

Author:

Tang Wei1ORCID,Lin Zilan2,Sharma Pritika1,Heering Gabriel1,Dworkin Brad2,Steinberg Amir3,Shakil Fouzia4,Schorr-Lesnick Beth2

Affiliation:

1. Department of Internal Medicine, New York Medical College, Valhalla, NY

2. Department of Gastroenterology and Hepatobiliary Diseases, New York Medical College, Valhalla, NY

3. Department of Hematology and Oncology, New York Medical College, Valhalla, NY

4. Department of Pathology, New York Medical College, Valhalla, NY

Abstract

ABSTRACT Alpha heavy chain disease (αHCD) is a rare variant of the mucosa-associated lymphoid tissue lymphoma characterized by expression of a monotypic truncated immunoglobulin α heavy chain. αHCD frequently involves the gastrointestinal (GI) tract, and its pathogenesis has been linked to clonal B-cell expansion from chronic immune stimulation by infectious agents. We report a rare case of GI αHCD with 5 concomitant pathogens identified on a GI multiplex real-time polymerase chain reaction panel, featured by persistent Campylobacter jejuni colonization and refractory giardiasis.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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