Myeloproliferative Neoplasms, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology

Author:

Gerds Aaron T.1,Gotlib Jason2,Ali Haris3,Bose Prithviraj4,Dunbar Andrew5,Elshoury Amro6,George Tracy I.7,Gundabolu Krishna8,Hexner Elizabeth9,Hobbs Gabriela S.10,Jain Tania11,Jamieson Catriona12,Kaesberg Paul R.13,Kuykendall Andrew T.14,Madanat Yazan15,McMahon Brandon16,Mohan Sanjay R.17,Nadiminti Kalyan V.18,Oh Stephen19,Pardanani Animesh20,Podoltsev Nikolai21,Rein Lindsay22,Salit Rachel23,Stein Brady L.24,Talpaz Moshe25,Vachhani Pankit26,Wadleigh Martha27,Wall Sarah28,Ward Dawn C.29,Bergman Mary Anne30,Hochstetler Cindy30

Affiliation:

1. 1Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

2. 2Stanford Cancer Institute;

3. 3City of Hope National Medical Center;

4. 4The University of Texas MD Anderson Cancer Center;

5. 5Memorial Sloan Kettering Cancer Center;

6. 6Roswell Park Comprehensive Cancer Center;

7. 7Huntsman Cancer Institute at the University of Utah;

8. 8Fred & Pamela Buffett Cancer Center;

9. 9Abramson Cancer Center at the University of Pennsylvania;

10. 10Massachusetts General Hospital Cancer Center;

11. 11The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

12. 12UC San Diego Moores Cancer Center;

13. 13UC Davis Comprehensive Cancer Center;

14. 14Moffitt Cancer Center;

15. 15UT Southwestern Simmons Comprehensive Cancer Center;

16. 16University of Colorado Cancer Center;

17. 17Vanderbilt-Ingram Cancer Center;

18. 18University of Wisconsin Carbone Cancer Center;

19. 19Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

20. 20Mayo Clinic Cancer Center;

21. 21Yale Cancer Center/Smilow Cancer Hospital;

22. 22Duke Cancer Institute;

23. 23Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

24. 24Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

25. 25University of Michigan Rogel Cancer Center;

26. 26O'Neal Comprehensive Cancer Center at UAB;

27. 27Dana-Farber/Brigham and Women’s Cancer Center;

28. 28The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

29. 29UCLA Jonsson Comprehensive Cancer Center; and

30. 30National Comprehensive Cancer Network.

Abstract

The classic Philadelphia chromosome–negative myeloproliferative neoplasms (MPN) consist of myelofibrosis, polycythemia vera, and essential thrombocythemia and are a heterogeneous group of clonal blood disorders characterized by an overproduction of blood cells. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for MPN were developed as a result of meetings convened by a multidisciplinary panel with expertise in MPN, with the goal of providing recommendations for the management of MPN in adults. The Guidelines include recommendations for the diagnostic workup, risk stratification, treatment, and supportive care strategies for the management of myelofibrosis, polycythemia vera, and essential thrombocythemia. Assessment of symptoms at baseline and monitoring of symptom status during the course of treatment is recommended for all patients. This article focuses on the recommendations as outlined in the NCCN Guidelines for the diagnosis of MPN and the risk stratification, management, and supportive care relevant to MF.

Publisher

Harborside Press, LLC

Subject

Oncology

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