THE ROLE OF CYTOREDUCTIVE SURGERY (CRS) AND INTRAPERITONEAL INTRAOPERATIVE CHEMOTHERAPY (IIC) IN THE TREATMENT OF PERITONEAL CARCINOMATOSIS FROM COLORECTAL ORIGIN-Reference-Cited by-同舟云学术

THE ROLE OF CYTOREDUCTIVE SURGERY (CRS) AND INTRAPERITONEAL INTRAOPERATIVE CHEMOTHERAPY (IIC) IN THE TREATMENT OF PERITONEAL CARCINOMATOSIS FROM COLORECTAL ORIGIN

Published:2017-03-30 Issue:1 Volume: Page:53-58
ISSN:2073-7556
Container-title:Koloproktologia
language:
Short-container-title:Koloproktologiâ

Author:

Shelygin Y. A.¹,Achkasov S. I.¹,Sushkov O. I.¹,Ponomarenko A. A.¹

Affiliation:

1. State Scientific Centre of Coloproctology

Abstract

AIM. To assess early results and survival in patients with CRS and IIC strategy. METHOD. 56 CRC with PC patients underwent CRS+IIC. pT4 stage occurred in 38 (67,5 %) pts. N+ status was detected in 39 (69 %) cases. In 44 (79 %) pts. carcinomatosiswas synchronous. PCI was rangedfrom 1 to 21 (Me=3). RESULTS. Mortality and morbidity rate in postoperative 30 days was 0 % and 14 %, respectively. The median disease-free survival (DFS) was 21 months. Multivariate analysis revealed that PCI (p=0,0007) and the presence of extraperitoneal metastases (p=0,0097) were independent negative predictors of DFS. The empirical analysis showed that level of PCI more than 8 was the predictor of negative prognosis (p=0,044). CONCLUSION. It has been shown that poor prognosis factors were PCI more than 8, and the presence of distant extraperitoneal metastases of CRC.

Publisher

Russian Association of Coloproctology

Subject

Materials Chemistry

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