New Insights into HIV Assembly and Trafficking-Reference-Cited by-同舟云学术

New Insights into HIV Assembly and Trafficking

Published:2011-08 Issue:4 Volume:26 Page:236-251
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Balasubramaniam Muthukumar¹,Freed Eric O.¹

Affiliation:

1. Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland

Abstract

Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly translocates to membrane to orchestrate particle production. The cell biology of HIV-1 Gag trafficking is currently one of the least understood aspects of HIV-1 replication. In this review, we highlight the current understanding of the cellular machinery involved in Gag trafficking and virus assembly.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00051.2010

Reference247 articles.

1. Anti-HIV-1 Therapeutics: From FDA-approved Drugs to Hypothetical Future Targets

2. Human Immunodeficiency Virus Type 1 Assembly, Release, and Maturation

3. Novel approaches to inhibiting HIV-1 replication

4. Recent progress in antiretrovirals – lessons from resistance

5. Virus maturation as a new HIV-1 therapeutic target

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