Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation-Reference-Cited by-同舟云学术

Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation

Published:2023-04-18 Issue:8 Volume:24 Page:7472
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Wang Desheng¹,Gomes Marta T.²,Mo Yanfei¹,Prohaska Clare C.²,Zhang Lu¹,Chelvanambi Sarvesh²³,Clauss Matthias A.²,Zhang Dongfang⁴^ORCID,Machado Roberto F.²,Gao Mingqi¹,Bai Yang¹²^ORCID

Affiliation:

1. Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China

2. Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA

3. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA

4. Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang 110122, China

Abstract

Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human endogenous retrovirus K(HERV-K), and human immunodeficiency virus (HIV), in part due to acute and chronic inflammation. In this review, we discuss the connections between HERV-K, HIV, SARS-CoV-2, and PAH, to stimulate research regarding new therapeutic options and provide new targets for the treatment of the disease.

Funder

National Nature Science Foundation of China

National Heart, Lung, and Blood Institute of the National Institutes of Health

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/8/7472/pdf

Reference142 articles.

1. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT);Humbert;Eur. Heart J.,2016

2. Pulmonary arterial hypertension: Pathogenesis and clinical management;Thenappan;BMJ,2018

3. The pathology of hypertensive pulmonary vascular disease; a description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects;Heath;Circulation,1958

4. HIV and inflammation;Decrion;Curr. HIV Res.,2005

5. HIV-related cardiovascular risk factors;Enferm. Infecc. Microbiol. Clin.,2009

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Does the interplay between human endogenous retrovirus K and extracellular vesicles contribute to aging?;Extracellular Vesicles and Circulating Nucleic Acids;2023-10-28

2. COVID-19. Biology, pathophysiology, and immunology: a pathologist view;Pathologica;2023-10

3. Exploring HERV-K (HML-2) Influence in Cancer and Prospects for Therapeutic Interventions;International Journal of Molecular Sciences;2023-09-27