The Role of Shear Stress on ET-1, KLF2, and NOS-3 Expression in the Developing Cardiovascular System of Chicken Embryos in a Venous Ligation Model-Reference-Cited by-同舟云学术

The Role of Shear Stress on ET-1, KLF2, and NOS-3 Expression in the Developing Cardiovascular System of Chicken Embryos in a Venous Ligation Model

Published:2007-12 Issue:6 Volume:22 Page:380-389
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Groenendijk Bianca C. W.¹²,Van der Heiden Kim²,Hierck Beerend P.²,Poelmann Robert E.²

Affiliation:

1. Department of Medical Biochemistry, Academic Medical Center, Amsterdam; and

2. Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands

Abstract

In this review, the role of wall shear stress in the chicken embryonic heart is analyzed to determine its effect on cardiac development through regulating gene expression. Therefore, background information is provided for fluid dynamics, normal chicken and human heart development, cardiac malformations, cardiac and vitelline blood flow, and a chicken model to induce cardiovascular anomalies. A set of endothelial shear stress-responsive genes coding for endothelin-1 (ET-1), lung Krüppel-like factor (LKLF/KLF2), and endothelial nitric oxide synthase (eNOS/NOS-3) are active in development and are specifically addressed.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00023.2007

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