Biogenic Amine Neurotransmitter Transporters: Just When You Thought You Knew Them

Author:

Blakely Randy D.1,DeFelice Louis J.1,Galli Aurelio1

Affiliation:

1. Departments of Pharmacology, Molecular Physiology and Biophysics, and Psychiatry, and Center for Molecular Neuroscience, Vanderbilt School of Medicine, Nashville, Tennessee

Abstract

Plasma membrane transporters have long been known to support the reuptake of biogenic amine neurotransmitters following release in the central and peripheral nervous systems. Using high-resolution imaging, patch-clamp and amperometric approaches, as well as molecular manipulations of transporter-regulatory pathways, surprising new details have been uncovered as to how transporters work and are influenced by signaling pathways and psychostimulants.

Publisher

American Physiological Society

Subject

Physiology

Reference57 articles.

1. Apparsundaram S, Galli A, DeFelice LJ, Hartzell HC, and Blakely RD. Acute regulation of norepinephrine transport: I. protein kinase C-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells.J Pharmacol Exp Ther287: 733–743, 1998.

2. Apparsundaram S, Sung U, Price RD, and Blakely RD. Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells.J Pharmacol Exp Ther299: 666–677, 2001.

3. GABA Transporter Currents Activated by Protein Kinase A Excite Midbrain Neurons during Opioid Withdrawal

4. Biogenic amine transporters: regulation in flux

5. Blakely RD, DeFelice LJ, and Hartzell HC. Molecular physiology of norepinephrine and serotonin transporters.J Exp Biol196: 263–281, 1994.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3