Carotid Body Inflammation: Role in Hypoxia and in the Anti-inflammatory Reflex-Reference-Cited by-同舟云学术

Carotid Body Inflammation: Role in Hypoxia and in the Anti-inflammatory Reflex

Published:2021-12-06 Issue: Volume: Page:
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Iturriaga Rodrigo¹²,Del Rio Rodrigo²³⁴,Alcayaga Julio⁵

Affiliation:

1. Laboratorio de Neurobiologia. Departamento de Fisiologia. Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, Pontificia Universidad Catolica de Chile, Santiago-1, Región, Chile

2. Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, Santiago, Chile

3. Laboratory of Cardiorespiratory Control, Department of Physiology, Pontificia Universidad Católica de Chile, Santiago, Chile

4. Centro de Envejecimiento y Regeneración (CARE), Pontificia Universidad Católica de Chile, Santiago, Chile

5. Laboratorio de Fisiología Celular, Facultad de Ciencias, Universidad de Chile, Santiago, Chile

Abstract

Emergent evidence indicates that the carotid body (CB) chemoreceptors may sense systemic inflammatory molecules, and is an afferent-arm of the anti-inflammatory reflex. Moreover, a pro-inflammatory milieu within the CB is involved in the enhanced CB chemosensory responsiveness to oxygen following sustained and intermittent hypoxia. In this review, we focus on the physio-pathological participation of CBs in inflammatory diseases, such as sepsis and intermittent hypoxia.

Funder

MINEDUC | CONICYT | Fondo Nacional de Desarrollo Científico y Tecnológico

Pontificia Universidad Catolica de Chile

Basal Centre for Excelence in Aging and Regeneration

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00031.2021

Reference96 articles.

1. Carotid body chemoreceptors: from natural stimuli to sensory discharges.