Dense-Core Secretory Granule Biogenesis

Author:

Kim Taeyoon1,Gondré-Lewis Marjorie C.1,Arnaoutova Irina1,Loh Y. Peng1

Affiliation:

1. Section on Cellular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland,

Abstract

The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational mechanisms.

Publisher

American Physiological Society

Subject

Physiology

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