Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging?

Author:

Wang Zhen-Bo1,Schatten Heide2,Sun Qing-Yuan1

Affiliation:

1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; and

2. Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, Missouri

Abstract

It is well documented that female fertility is decreased with advanced maternal age due to chromosome abnormality in oocytes. Increased chromosome missegregation is mainly caused by centromeric cohesion reduction. Other factors such as weakened homologous recombination, improper spindle organization, spindle assembly checkpoint (SAC) malfunction, chromatin epigenetic changes, and extra-oocyte factors may also cause chromosome errors.

Publisher

American Physiological Society

Subject

Physiology

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