Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway-Reference-Cited by-同舟云学术

Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway

Published:2005-08 Issue:4 Volume:20 Page:271-284
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Thong Farah S. L.¹,Dugani Chandrasagar B.¹²,Klip Amira¹²

Affiliation:

1. Programme in Cell Biology, The Hospital for Sick Children, and

2. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

Abstract

Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the plasma membrane and minimally reducing its endocytosis. The round trip of GLUT4 is intricately regulated by diverse signaling molecules impinging on specific compartments. Here we highlight the key molecular signals that are turned on and off by insulin to accomplish this task.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00017.2005

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