From “Hunger Hormone” to “It’s Complicated”: Ghrelin Beyond Feeding Control

Author:

Deschaine Sara L.1ORCID,Leggio Lorenzo12345ORCID

Affiliation:

1. Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Baltimore and Bethesda, Maryland

2. Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland

3. Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, School of Public Health, Brown University, Providence, Rhode Island

4. Division of Addiction Medicine, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland

5. Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia

Abstract

Discovered as a peptide involved in releasing growth hormone, ghrelin was initially characterized as the “hunger hormone.” However, emerging research indicates that ghrelin appears to play an important part in relaying information regarding nutrient availability and value and adjusting physiological and motivational processes accordingly. These functions make ghrelin an interesting therapeutic candidate for metabolic and neuropsychiatric diseases involving disrupted nutrition that can further potentiate the rewarding effect of maladaptive behaviors.

Funder

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

HHS | NIH | National Institute on Drug Abuse

Publisher

American Physiological Society

Subject

Physiology

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