Oxygen Sensing and Homeostasis-Reference-Cited by-同舟云学术

Oxygen Sensing and Homeostasis

Published:2015-09 Issue:5 Volume:30 Page:340-348
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Prabhakar Nanduri R.¹^ORCID,Semenza Gregg L.²³

Affiliation:

1. Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois;

2. Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland; and

3. McKusick-Nathans Institute of Genetic Medicine and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland

Abstract

The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)

HHS | NIH | National Human Genome Research Institute (NHGRI)

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00022.2015

Reference96 articles.

1. Measurement of carotid body blood flow in cats by use of radioactive microspheres

2. Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains