Affiliation:
1. Institute of Physiology, Regensburg, Germany,
Abstract
The gastric H+-K+-ATPase pumps H+into the lumen and takes up K+in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+channels play a pivotal role in replenishing K+in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.
Publisher
American Physiological Society
Cited by
50 articles.
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