Affiliation:
1. Departments of Cell and Tissue Biology, and
2. Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California
Abstract
Changes in intracellular pH regulate many cell behaviors, including proliferation, migration, and transformation. However, our understanding of how physiological changes in pH affect protein conformations and macromolecular assemblies is limited. We present design principles, current modeling predictions, and examples of pH sensors or proteins that have activities or ligand-binding affinities that are regulated by changes in intracellular pH.
Publisher
American Physiological Society
Cited by
217 articles.
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