Islet Inflammation Impairs the Pancreatic β-Cell in Type 2 Diabetes-Reference-Cited by-同舟云学术

Islet Inflammation Impairs the Pancreatic β-Cell in Type 2 Diabetes

Published:2009-12 Issue:6 Volume:24 Page:325-331
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Donath Marc Y.¹,Böni-Schnetzler Marianne¹,Ellingsgaard Helga¹,Ehses Jan A.¹

Affiliation:

1. Division of Endocrinology, Diabetes, and Nutrition, and Center for Integrated Human Physiology, University Hospital of Zürich, Zürich, Switzerland

Abstract

Onset of Type 2 diabetes occurs when the pancreatic β-cell fails to adapt to the increased insulin demand caused by insulin resistance. Morphological and therapeutic intervention studies have uncovered an inflammatory process in islets of patients with Type 2 diabetes characterized by the presence of cytokines, immune cells, β-cell apoptosis, amyloid deposits, and fibrosis. This insulitis is due to a pathological activation of the innate immune system by metabolic stress and governed by IL-1 signaling. We propose that this insulitis contributes to the decrease in β-cell mass and the impaired insulin secretion observed in patients with Type 2 diabetes.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00032.2009

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