Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy-Reference-Cited by-同舟云学术

Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy

Published:2016-07 Issue:4 Volume:31 Page:294-299
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Sapp Valerie¹,Jain Mohit¹,Liao Ronglih²

Affiliation:

1. Departments of Medicine & Pharmacology, University of California San Diego, San Diego, California; and

2. Division of Genetics and Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

Abstract

Proteotoxicity refers to toxic stress caused by misfolded proteins of extrinsic or intrinsic origin and plays an integral role in the pathogenesis of cardiovascular diseases. Herein, we provide an overview of the current understanding of mechanisms underlying proteotoxicity and its contribution in the pathogenesis of amyloid cardiomyopathy.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00047.2015

Reference55 articles.

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2. Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs

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4. Human Amyloidogenic Light Chains Directly Impair Cardiomyocyte Function Through an Increase in Cellular Oxidant Stress

5. Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes

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