Author:
Braidy Nady,Gai Wei-Ping,Xu Ying Hua,Sachdev Perminder,Guillemin Gilles J,Jiang Xing-Mai,Ballard J William O,Horan Martin P,Fang Zhi Ming,Chong Beng H,Chan DanielKam Yin
Abstract
Abstract
The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson’s disease (PD). In this study, we show that α-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblasts in vitro. Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function, leading to cellular degeneration and cell death, provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells.
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neurology (clinical)
Cited by
76 articles.
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