Subthalamic deep brain stimulation of an anatomically detailed model of the human hyperdirect pathway-Reference-Cited by-同舟云学术

Subthalamic deep brain stimulation of an anatomically detailed model of the human hyperdirect pathway

Published:2022-05-01 Issue:5 Volume:127 Page:1209-1220
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Bingham Clayton S.¹^ORCID,McIntyre Cameron C.¹²^ORCID

Affiliation:

1. Department of Biomedical Engineering, Duke University, Durham, North Carolina

2. Department of Neurosurgery, Duke University, Durham, North Carolina

Abstract

We used biophysical models to study pathway recruitment and conduction latencies of the hyperdirect pathway (HDP) in response to subthalamic deep brain stimulation (DBS). The model system allowed us to assess the influence of increased anatomical realism on pathway activity and the possibility of identifying HDP activity in evoked potentials (EPs) recorded in either the subthalamic nucleus (STN) or cortex. The model predicts that HDP activation is accentuated by complex axonal branching in the STN.

Funder

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00004.2022

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