Encoding of graded changes in spatial specificity of prior cues in human visual cortex

Abstract

Prior information about the relevance of spatial locations can vary in specificity; a single location, a subset of locations, or all locations may be of potential importance. Using a contrast-discrimination task with four possible targets, we asked whether performance benefits are graded with the spatial specificity of a prior cue and whether we could quantitatively account for behavioral performance with cortical activity changes measured by blood oxygenation level-dependent (BOLD) imaging. Thus we changed the prior probability that each location contained the target from 100 to 50 to 25% by cueing in advance 1, 2, or 4 of the possible locations. We found that behavioral performance (discrimination thresholds) improved in a graded fashion with spatial specificity. However, concurrently measured cortical responses from retinotopically defined visual areas were not strictly graded; response magnitude decreased when all 4 locations were cued (25% prior probability) relative to the 100 and 50% prior probability conditions, but no significant difference in response magnitude was found between the 100 and 50% prior probability conditions for either cued or uncued locations. Also, although cueing locations increased responses relative to noncueing, this cue sensitivity was not graded with prior probability. Furthermore, contrast sensitivity of cortical responses, which could improve contrast discrimination performance, was not graded. Instead, an efficient-selection model showed that even if sensory responses do not strictly scale with prior probability, selection of sensory responses by weighting larger responses more can result in graded behavioral performance benefits with increasing spatial specificity of prior information.