Author:
Nelken Israel,Bizley Jennifer K.,Nodal Fernando R.,Ahmed Bashir,Schnupp Jan W. H.,King Andrew J.
Abstract
We have adapted a new approach for intrinsic optical imaging, in which images were acquired continuously while stimuli were delivered in a series of continually repeated sequences, to provide the first demonstration of the large-scale tonotopic organization of both primary and nonprimary areas of the ferret auditory cortex. Optical responses were collected during continuous stimulation by repeated sequences of sounds with varying frequency. The optical signal was averaged as a function of time during the sequence, to produce reflectance modulation functions (RMFs). We examined the stability and properties of the RMFs and show that their zero-crossing points provide the best temporal reference points for quantifying the relationship between the stimulus parameter values and optical responses. Sequences of different duration and direction of frequency change gave rise to comparable results, although in some cases discrepancies were observed, mostly between upward- and downward-frequency sequences. We demonstrated frequency maps, consistent with previous data, in primary auditory cortex and in the anterior auditory field, which were verified with electrophysiological recordings. In addition to these tonotopic gradients, we demonstrated at least 2 new acoustically responsive areas on the anterior and posterior ectosylvian gyri, which have not previously been described. Although responsive to pure tones, these areas exhibit less tonotopic order than the primary fields.
Publisher
American Physiological Society
Subject
Physiology,General Neuroscience
Reference49 articles.
1. Suprathreshold Auditory Cortex Activation Visualized by Intrinsic Signal Optical Imaging
2. Relationships between orientation-preference pinwheels, cytochrome oxidase blobs, and ocular-dominance columns in primate striate cortex.
3. Berne RM and Levy MN. Physiology. St. Louis, MO: Mosby, 1993.
4. Bizley JK, Nodal FR, Bajo VM, Moore DR, and King AJ. Establishing cytoarchitectronic divisions in ferret auditory cortex. Abstracts of the 26th mid-winter meeting of the Association for Research in Otolaryngology, Daytona Beach, FL, 2003.
5. Iso-orientation domains in cat visual cortex are arranged in pinwheel-like patterns
Cited by
71 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献