New Disguises for an Old Channel: MaxiK Channel β-Subunits

Author:

Orio Patricio12,Rojas Patricio12,Ferreira Gonzalo3,Latorre Ramón124

Affiliation:

1. Centro de Estudios Científicos (CECS), Valdivia;

2. Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile;

3. Departamento de Biofísica, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay

4. Department of Physiology and Anesthesiology, UCLA School of Medicine, Los Angeles, California 90095; and

Abstract

Ca2+-activated K+ channels of large conductance (MaxiK or BK channels) control a large variety of physiological processes, including smooth muscle tone, neurosecretion, and hearing. Despite being coded by a single gene (Slowpoke), the diversity of MaxiK channels is great. Regulatory b-subunits, splicing, and metabolic regulation create this diversity fundamental to the adequate function of many tissues.

Publisher

American Physiological Society

Subject

Physiology

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