Na<sub>V</sub>1.9 current in muscle afferent neurons is enhanced by substances released during muscle activity-Reference-Cited by-同舟云学术

Na_V1.9 current in muscle afferent neurons is enhanced by substances released during muscle activity

Published:2022-10-01 Issue:4 Volume:128 Page:739-750
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Sukhanova Khrystyna Yu¹,Koirala Ankeeta¹,Elmslie Keith S.¹^ORCID

Affiliation:

1. The Baker Laboratory of Pharmacology, Department of Pharmacology, Kirksville College of Osteopathic Medicine, A.T. Still University of Health Sciences, Kirksville, Missouri

Abstract

G-protein-coupled receptor (GPCR) activation increases action potential activity in muscle afferents to produce the exercise pressor reflex (EPR), but the mechanisms are incompletely understood. We provide evidence that NaV1.9 current is synergistically enhanced by application of a mixture of metabolites potentially released during muscle contraction. The enhancement of NaV1.9 current is likely one mechanism by which GPCR activation generates the EPR and the inappropriate activation of the EPR in patients with cardiovascular disease.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

Kirksville College of Osteopathic Medicine, A.T. Still University of Health Sciences

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00116.2022

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2. The exercise pressor reflex and peripheral artery disease

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4. Inflammatory Mediators Increase Nav1.9 Current and Excitability in Nociceptors through a Coincident Detection Mechanism

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