Impact of handgrip exercise and ischemic preconditioning on local and remote protection against endothelial reperfusion injury in young men

Author:

Bannell Daniel J.1ORCID,Montrezol Fabio T.2,Maxwell Joseph D.1ORCID,Somani Yasina B.1,Low David A.1ORCID,Thijssen Dick H. J.13,Jones Helen1ORCID

Affiliation:

1. Research Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom

2. Federal University of Sao Paulo, Santos, Brazil

3. Department of Physiology, Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

Abstract

Ischemic preconditioning (IPC), cyclical bouts of nonlethal ischemia, provides immediate protection against ischemic injury, which is evident both locally and remotely. Given the similarities in protective effects of exercise with ischemic preconditioning, we examined whether handgrip exercise also offers protection against endothelial ischemia-reperfusion (IR) injury and whether this protection is equally present in the local (exercised) and remote (contralateral, nonexercised) arm. Fifteen healthy males (age, 24 ± 3 yr; body mass index, 25 ± 2 kg/m2) attended the laboratory on three occasions. Bilateral brachial artery flow-mediated dilation (FMD) was examined at rest and after a temporary IR injury in the upper arm. Before the IR injury, in the dominant (local) arm, participants performed (randomized, counterbalanced): 1) 4 × 5 min unilateral handgrip exercise (50% maximal voluntary contraction), 2) 4 × 5 min unilateral IPC (220 mmHg), or 3) 4 × 5 min rest (control). Data were analyzed using repeated-measures general linear models. Allometrically scaled FMD declined after IR in the control condition (4.6 ± 1.3% to 2.2 ± 1.7%, P < 0.001), as well as following handgrip exercise (4.6 ± 1.6% to 3.4 ± 1.9%, P = 0.01), however, was significantly attenuated with IPC (4.5 ± 1.4% to 3.8 ± 3.5%, P = 0.14). There were no differences between the local and remote arm. Our findings reinforce the established protective effects of IPC in young, healthy males and also highlight a novel strategy to protect against IR injury with handgrip exercise, which warrants further study.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Single and 7-day handgrip and squat exercise prevents endothelial ischemia-reperfusion injury in individuals with cardiovascular disease risk factors;American Journal of Physiology-Regulatory, Integrative and Comparative Physiology;2024-01-01

2. Handgrip exercise in patients scheduled for cardiac surgery to attenuate troponin release: a feasibility study;American Journal of Physiology-Heart and Circulatory Physiology;2023-11-01

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