Lymphatic pump function curves in awake sheep

Author:

Drake R. E.1,Dhother S.1,Oppenlander V. M.1,Gabel J. C.1

Affiliation:

1. Department of Anesthesiology, University of Texas-Houston MedicalSchool 77030, USA.

Abstract

We determined the relationship between flow rate and inflow pressure for intestinal lymphatic vessels in six sheep. First we anesthetized the sheep and cannulated both ends of a 6- to 10-cm-long segment of intestinal lymphatic. We allowed the sheep to recover from the anesthesia for 2-24 h. To determine the flow rate-inflow pressure relationship, we recorded the inflow pressure and infused Ringer solution into the lymphatic at rates from 34 to 510 microliters/min. The flow rate-pressure relationship was not linear and it had two regions. For flow rates less than approximately 150 microliters/min, inflow pressure was greater than outflow pressure. Thus the lymphatic pumped fluid against a pressure gradient. For flow rates > 150 microliters/min, inflow pressure was greater than outflow pressure, and we attributed most of the flow to the favorable inflow-outflow pressure gradient (passive flow). When we used verapamil to inhibit lymphatic pumping, we found no flow for inflow pressure less than outflow pressure, and flow increased linearly for inflow pressure greater than outflow pressure. Our data for actively pumping lymphatic vessels are consistent with the flow vs. pressure relationships derived from mathematical models of the lymphatic pump. Furthermore, our data with verapamil confirm that active lymphatic pumping was responsible for the nonlinear flow vs. pressure relationship for the lymphatic vessels.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Modelling the lymphatic system: challenges and opportunities;Journal of The Royal Society Interface;2012-01-11

2. First-order approximation for the pressure-flow relationship of spontaneously contracting lymphangions;American Journal of Physiology-Heart and Circulatory Physiology;2008-05

3. Unique role of skeletal muscle contraction in vertical lymph movement in anurans;Journal of Experimental Biology;2007-11-15

4. Lymphangion coordination minimally affects mean flow in lymphatic vessels;American Journal of Physiology-Heart and Circulatory Physiology;2007-08

5. Arnold Heller and the lymph pump;Acta Physiologica Scandinavica;2005-11

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