Baroreflex stabilization of the double (pressure-rate) product at 0.05 Hz in conscious rabbits-Reference-Cited by-同舟云学术

Baroreflex stabilization of the double (pressure-rate) product at 0.05 Hz in conscious rabbits

Published:2002-06-01 Issue:6 Volume:282 Page:R1746-R1753
ISSN:0363-6119
Container-title:American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
language:en
Short-container-title:American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Author:

Van Vliet Bruce N.¹,Belforti Francesca²,Montani Jean-Pierre²

Affiliation:

1. Faculty of Medicine, Division of Basic Medical Sciences, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3V6; and

2. Institute of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland

Abstract

The product of heart rate (HR) and systolic blood pressure (SBP), the double product (DP), is an indirect index of cardiac oxygen consumption. We used spectral analysis to test the hypothesis that baroreflex adjustments of HR stabilize the DP during spontaneous variations in SBP. SBP and HR were recorded by telemetry in five male conscious rabbits. HR and SBP power spectra each exhibited a low frequency peak at ∼0.05 Hz that was associated with high (>0.5) spectral coherence and a positive phase relationship between SBP and HR (SBP leading). A prominent peak was absent in the spectra of their product, suggesting that SBP and HR interacted to reduce DP variability in this frequency region. In contrast, a prominent 0.05-Hz peak was present in the power spectrum of calculated surrogates of the DP in which reflex interactions between HR and SBP had been removed. Our results suggest that baroreflex adjustments of HR stabilize the DP during spontaneous low-frequency variations in SBP in conscious rabbits.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/ajpregu.00529.2001

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