High-frequency oscillations within early and late phases of the phrenic neurogram

Abstract

Spectral analyses were performed on phrenic neurogram recordings from 18 cats to identify high-frequency oscillations (HFOs) inherent in the signals at different phases of inspiratory activity. Gating the analysis for the entire inspiratory phase resulted in dual spectral HFOs (27 and 83 Hz), both of which persisted when the analysis was repeated on the later phase of phrenic inspiratory activity alone (29 and 82 Hz). A third pass at the same data, gating for just the early phase of phrenic discharge, however, resulted in single spectral HFOs at the higher frequency only (86 Hz). Because both early and late recruited phrenic motoneurons carry both higher and lower spectral frequencies, these results demonstrate that the lower frequency HFO is distinctly delayed in onset compared with the higher frequency HFO, the latter of which is believed to have a brain stem origin. This delayed onset may be important in identifying the source of the lower frequency HFO, which appears to be specific to various respiratory efferent systems.