Born Again Bone: Tissue Engineering for Bone Repair

Author:

Braddock Martin1,Houston Parul2,Campbell Callum2,Ashcroft Patrick3

Affiliation:

1. Disease Cell Biology and

2. Cardiovascular Systems Units, GlaxoWellcome Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, England; and

3. Department of Orthopaedics, University of Aberdeen Medical School, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB9 2ZD, Scotland

Abstract

Destruction of bone tissue due to disease and inefficient bone healing after traumatic injury may be addressed by tissue engineering techniques. Growth factor, cytokine protein, and gene therapies will be developed, which, in conjunction with suitable carriers, will regenerate missing bone or help in cases of defective healing.

Publisher

American Physiological Society

Subject

Physiology

Reference20 articles.

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3. Boyne PJ, Marx RE, Nevins M, Triplett G, Lazaro E, Lilly LC, Alder M, and Nummikoski P. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodontics Restorative Dent 17: 11–25, 1997.

4. Braddock M, Schwachtgen J-L, Houston P, Dickson MC, Lee MJ, and Campbell CJ. Fluid shear stress modulation of gene expression in endothelial cells. News Physiol Sci 13: 241–246, 1988.

5. Tissue Repair with a Therapeutic Transcription Factor

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