Fluid Shear Stress Modulation of Gene Expression in Endothelial Cells-Reference-Cited by-同舟云学术

Fluid Shear Stress Modulation of Gene Expression in Endothelial Cells

Published:1998-10 Issue:5 Volume:13 Page:241-246
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Braddock Martin¹,Schwachtgen Jean-Luc¹,Houston Parul¹,Dickson Marion C.¹,Lee Michael J.¹,Campbell Callum J.¹

Affiliation:

1. M. Braddock, J.-L. Schwachtgen, P. Houston, M. C. Dickson, M. J. Lee, and C. J. Campbell are in the Vascular Diseases Research Unit, Glaxo-Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK.

Abstract

The vascular endothelium, lining the blood vessel wall, is constantly exposed to wall shear stresses generated by flowing blood. Gene regulation, critical for endothelial cell function, depends on complex interactions at the promoter level and utilizes overlapping signal transduction cascades to activate the expression of genes involved in many biological processes.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiologyonline.1998.13.5.241

Reference15 articles.

1. Braddock, M., P. Houston, M. C. Dickson, J. McVey, and C. J. Campbell. Fluid shear stress activates the tissue factor promoter in vascular endothelial cells via upregulation of the cellular transcription factor, Egr-1.J. Vasc. Res.33: 11, 1995.

2. MAP Kinase Activation by Flow in Endothelial Cells

3. Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.

4. Stimulation of Transcription Factors NFκB and AP1 in Endothelial Cells Subjected to Shear Stress

5. Lawrence, M. B., C. W. Smith, S. G. Eskin, and L. V. McIntire. Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured endothelium.Blood75: 227–237, 1990.

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