Mitochondrial sequencing identifies long noncoding RNA features that promote binding to PNPase

Author:

Taylor Andrew D.12ORCID,Hathaway Quincy A.134ORCID,Kunovac Amina12ORCID,Pinti Mark V.25,Newman Mackenzie S.6,Cook Chris C.7,Cramer Evan R.8,Starcovic Sarah A.8,Winters Michael T.9,Westemeier-Rice Emily S.9,Fink Garrett K.1,Durr Andrya J.12ORCID,Rizwan Saira12,Shepherd Danielle L.12,Robart Aaron R.8,Martinez Ivan9,Hollander John M.12ORCID

Affiliation:

1. Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia, United States

2. Mitochondria, Metabolism, and Bioenergetics Working Group, West Virginia University School of Medicine, Morgantown, West Virginia, United States

3. Heart and Vascular Institute, West Virginia University, Morgantown, West Virginia, United States

4. Department of Medical Education, West Virginia University School of Medicine, Morgantown, West Virginia, United States

5. West Virginia University School of Pharmacy, Morgantown, West Virginia, United States

6. Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia, United States

7. Cardiovascular and Thoracic Surgery, West Virginia University School of Medicine, Morgantown, West Virginia, United States

8. Department of Biochemistry, West Virginia University School of Medicine, Morgantown, West Virginia, United States

9. Department of Microbiology, Immunology, and Cell Biology, West Virginia University Cancer Institute, School of Medicine, Morgantown, West Virginia, United States

Abstract

Long noncoding RNAs (lncRNAs) are relatively novel RNAs with increasingly prominent roles in regulating genetic expression, mainly in the nucleus but more recently in regions such as the mitochondrion. This study explores how lncRNAs interact with polynucleotide phosphorylase (PNPase), a protein that regulates RNA import into the mitochondrion. Machine learning identified several RNA structural features that improved lncRNA binding to PNPase, which may be useful in targeting RNA therapeutics to the mitochondrion.

Funder

HHS | NIH | National Institute of Environmental Health Sciences

HHS | NIH | National Institute of General Medical Sciences

National Science Foundation

West Virginia IDeA Network of Biomedical Resarch WV-INBRE | National Institute of Health

WVU Clinical Translational Sciences Institute

Community Foundation for the Ohio Valley Whipkey Trust

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3