Endogenous microRNA sponges: evidence and controversy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg.2016.20.pdf
Reference146 articles.
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3. Broderick, J. A. & Zamore, P. D. Competitive endogenous RNAs cannot alter microRNA function in vivo. Mol. Cell 54, 711–713 (2014).
4. Denzler, R., Agarwal, V., Stefano, J., Bartel, D. P. & Stoffel, M. Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. Mol. Cell 54, 766–776 (2014). This study used quantitative measurements of target abundance and controlled overexpression to conclude that physiological expression of individual competing transcripts was insufficient to silence miR-122, a miRNA that is highly expressed in liver.
5. Bosson, A. D., Zamudio, J. R. & Sharp, P. A. Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition. Mol. Cell 56, 347–359 (2014). This study measured the active miRNA target pool using AGO iCLIP to show that the majority of active miRNAs are probably not susceptible to ceRNA competition. Although exceptionally low target abundance can create a scenario of physiological RNA competition, such as the example of the miR-25 miRNA family.
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