HIF-1 contributes to autophagy activation via BNIP3 to facilitate renal fibrosis in hypoxia in vitro and UUO in vivo-Reference-Cited by-同舟云学术

HIF-1 contributes to autophagy activation via BNIP3 to facilitate renal fibrosis in hypoxia in vitro and UUO in vivo

Published:2024-03-01 Issue:3 Volume:326 Page:C935-C947
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Liu Jing¹²,Livingston Man J.²^ORCID,Dong Guie²,Wei Qingqing²^ORCID,Zhang Ming²,Mei Shuqin²³,Zhu Jiefu⁴,Zhang Chun¹^ORCID,Dong Zheng²^ORCID

Affiliation:

1. Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

2. Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, Georgia, United States

3. Department of Nephrology, Second Affiliated Hospital of Naval Medical University, Shanghai, China

4. Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China

Abstract

Autophagy has been reported to participate in renal fibrosis, but its role and underlying activation mechanism is unclear. In this study, we report the role of HIF-1 in autophagy activation in models of renal fibrosis and further investigate the underlying mechanism.

Funder

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

National Natural Science Foundation of China

湖北省科技厅 | Natural Science Foundation of Hubei Province

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00458.2023

Reference52 articles.

1. Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

2. Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

3. Renal tubule injury: a driving force toward chronic kidney disease

4. The fibrogenic niche in kidney fibrosis: components and mechanisms

5. Mechanisms of Renal Fibrosis

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